Blood α-Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies.

ABSTRACT:

Objective

Aggregation of misfolded α-synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBDs), including Parkinson's disease (PD), and dementia with Lewy bodies (DLB) disease. Although evidence exists for aSyn "strains," conformations with distinct biological properties, biomarkers for PD versus DLB are lacking. Here, we used monoclonal antibodies selective for two different in vitro aSyn species - termed strain A and B - to evaluate human brain tissue, cerebrospinal fluid (CSF), and plasma.

Methods

Using these antibodies, we characterized specific aSyn species in human specimens from neurologically normal individuals and individuals with LBD using enzyme-linked immunosorbent assay (ELISA), Western blot, and immunohistochemistry. We also char

SUBMITTER: Kannarkat GT 

PROVIDER: S-EPMC12262490 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature