Anterior cingulate folding pattern is altered in autism spectrum disorder.

ABSTRACT: Neuroimaging research has identified focal differences in the cerebral cortex of individuals with autism spectrum disorder (ASD), particularly in the cortical folds (sulci) within higher-level association cortices. The present study investigated the sulcal patterning and morphology of the anterior cingulate cortex (ACC) in individuals with ASD compared to neurotypical (NT) individuals for the first time. We used neuroimaging data from 50 NT and 50 ASD participants. All participants were under 20 years old and male. The two groups were age-matched. Using established criteria and cortical reconstructions generated from each participant's T1-weighted magnetic resonance imaging scans with FreeSurfer, we identified the defining sulcal feature of ACC, the variably present paracingulate sulcus (P

SUBMITTER: Willbrand EH 

PROVIDER: S-EPMC12262505 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature