Competing Programs Shape Cortical Sensorimotor-Association Axis Development.

ABSTRACT: The neocortex is organized along a dominant sensorimotor-to-association (S-A) axis, anchored by modality-specific primary sensorimotor areas at one end and transmodal association areas that form distributed networks supporting abstract cognition at the other. The developmental mechanisms shaping this axis remain elusive. Here, we present converging multispecies evidence supporting the Multinodal Induction-Exclusion in Network Development (MIND) model, in which S-A patterning is governed by competing processes of induction and exclusion, driven by opposing transcriptomically-defined identity programs emerging from different nodes. Key molecular and connectional features of association cortices arise through pericentral programs, originating around fronto-temporal poles and partially regulat

SUBMITTER: Tsyporin J 

PROVIDER: S-EPMC12262509 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature