Synergistic effects of <i>APOE</i> ε4 and Alzheimer's pathology on the neural correlates of episodic remembering in cognitively unimpaired older adults.

ABSTRACT: Amyloid-β (Aβ) and tau pathology begin accumulating decades before clinical symptoms and are influenced by APOE ε4, a key genetic risk factor for Alzheimer's disease (AD). Although the presence of Aβ, tau, and APOE ε4 are thought to impact brain function, their effects on the neural correlates of episodic memory retrieval in preclinical AD remains unknown. We investigated this question in 159 cognitively unimpaired older adults (mean age, 68.9±5.8 years; 57% female) in the Stanford Aging and Memory Study. Participants completed an associative memory task concurrent with functional MRI. Aβ was measured using CSF Aβ₄₂/Aβ₄₀ or Florbetaben-PET imaging and tau was measured using CSF pTau₁₈₁. Hippocampal univariate activity and cortical reinstatemen

SUBMITTER: Trelle AN 

PROVIDER: S-EPMC12262513 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature