Immune pathways and perinatal environmental exposures contribute to epigenetic gestational age prediction and acceleration.

ABSTRACT: DNA methylation (DNAm), capturing biological gestational age (GA) and epigenetic gestational age acceleration (EGAA), can be modified by environmental exposures. The Asthma&Allergy array is a new DNAm array developed with content focused on asthma and allergy loci. The association between content on the Asthma&Allergy array and chronological GA and EGAA has not been evaluated alone or in the context of perinatal exposures. We performed an epigenome wide association study(EWAS) based on chronological GA at single CpG sites and regions. We further constructed a multi-CpG site methylation model to predict chronological GA in cord blood from 391 newborn children from a Detroit-based birth cohort. Associations between perinatal environmental factors with GA, epigenetic gestational age (EGA), an

SUBMITTER: Eapen AA 

PROVIDER: S-EPMC12262535 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature