Spatially-explicit genomics of <i>An. gambiae s.l</i> uncovers fine-scale population structure and mechanisms of insecticide resistance.

ABSTRACT: Progress in malaria control in sub-Saharan Africa is stalling, partly due to the spread of insecticide resistance in Anopheles vectors. Monitoring the evolution of insecticide resistance alleles and their spatial heterogeneity is important for malaria control programmes, and genomic surveillance has emerged as a pivotal tool for this purpose. Earlier genomics research has typically employed convenience-based sampling, and research has yet to be performed to optimise sampling regimens for malaria vector genomics. In an earlier study, we developed a spatially explicit sampling framework that considers the underlying ecology to enable sampling mosquitoes with reduced bias. We applied this framework to sample and perform whole-genome sequencing on 485 individual specimens of An. gamb

SUBMITTER: Nagi SC 

PROVIDER: S-EPMC12262541 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature