Genetic mapping of lifespan and mitochondrial stress response in <i>C. elegans</i>.

ABSTRACT: The mitochondrial unfolded protein response (UPR^mt) is one of the mito-nuclear regulatory circuits that restores mitochondrial function upon stress conditions, promoting metabolic health and longevity. However, the complex gene interactions that govern this pathway and its role in aging and healthspan remain to be fully elucidated. Here, we activated the UPR^mt using doxycycline (Dox) in a genetically diverse C. elegans population comprising 85 strains and observed large variation in Dox-induced lifespan extension across these strains. Through multi-omic data integration, we identified an aging-related molecular signature that was partially reversed by Dox. To identify the mechanisms underlying Dox-induced lifespan extension, we applied quantitative trait locus

SUBMITTER: Li X 

PROVIDER: S-EPMC12262559 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature