Multiple autism genes influence GABA neuron remodeling via distinct developmental trajectories.

ABSTRACT: Variation in over 100 genes are now associated with increased risk for autism and related neurodevelopmental condition, but how this variation results in distinct and overlapping behavioral changes is still not well understood. Recent efforts have focused on screening many autism genes at once for functional and phenotypic convergence, and identified subsets that are crucial for many early steps of neurodevelopment. Few studies have screened later steps of neurodevelopment, circuit function, circuit plasticity, or behaviors. We screened twenty conserved autism-associated genes for impact on experience-dependent neuron remodeling in C. elegans. Loss of unc-44/ANK2, set-4/KMT5B, daf-18/PTEN, gap-2/SYNGAP1, and chd-1/CHD8 increased, while CACNA2D3/unc-36 dec

SUBMITTER: Zoga K 

PROVIDER: S-EPMC12262565 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature