Aging murine peritoneal macrophages undergo female-specific remodeling driven by hormone-dependent and independent mechanisms.

ABSTRACT: Aging is a complex process characterized by a progressive decline in physiological functions driven by both biological and environmental factors, with notable differences between sexes. Immune function is strongly influenced by biological sex, affecting both innate and adaptive immune responses, including macrophage behavior. In this study, we investigated the effects of age and sex on the immune cell composition within the peritoneal cavity niche and identified macrophages as the most affected cell type. Macrophages, as central components of the innate immune system, play critical roles in maintaining tissue homeostasis and responding to infections. Here, we find that aging induces sex-specific remodeling of murine peritoneal macrophage transcriptomic and epigenomic landscapes. Consistent

SUBMITTER: Lu RJ 

PROVIDER: S-EPMC12262579 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature