CRISPR RiPCA for Investigating eIF4E-m⁷GpppX Capped mRNA Interactions.

ABSTRACT: Post-transcriptional modifications expand the information encoded by an mRNA. These dynamic and reversible modifications are specifically recognized by reader RNA-binding proteins (RBPs), which mediate the regulation of gene expression, RNA processing, localization, stability, and translation. Given their crucial functions, any disruptions in the normal activity of these readers can have significant implications for cellular health. Consequently, the dysregulation of these RBPs has been associated with neurodegenerative disorders, cancers, and viral infections. Therefore, there has been growing interest in targeting reader RBPs as a potential therapeutic strategy since developing molecules that restore proper RNA processing and function may offer a promising avenue for treating diseases. I

SUBMITTER: Vega-Hernandez G 

PROVIDER: S-EPMC12262620 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature