Dynamic recruitment of PV interneurons in the somatosensory cortex induced by experience dependent plasticity.

ABSTRACT: Adaptive circuit plasticity plays crucial roles in the brain during development, learning, sensory experience, and after injury. During chronic whisker trimming, a well-studied paradigm for inducing experience dependent plasticity, whisker representations in the somatosensory barrel cortex (S1BF) undergo remapping, with expansion of maps for spared whiskers and contraction of maps for trimmed whiskers. At the cellular level, excitatory pyramidal cells in Layer 2/3 shift their whisker tuning, increasing selectivity to spared whiskers and away from deprived whiskers. While these changes are well documented, the circuit mechanisms regulating experience-dependent plasticity remain incompletely characterized. Parvalbumin (PV) interneurons play important roles in regulating the spatial and tempo

SUBMITTER: Campos B 

PROVIDER: S-EPMC12262626 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature