<i>APOE4</i> drives widespread changes to the hepatic proteome and alters metabolic function.

ABSTRACT: Apolipoprotein E (APOE) is essential for lipid homeostasis and has been extensively studied in the central nervous system, particularly in the context of Alzheimer's disease (AD). Individuals carrying an APOE4 allele have an increased risk of AD and exhibit deficits in energy metabolism, including glucose utilization and mitochondrial dysfunction. While the role of APOE in the liver is well characterized, the impact of APOE genetic variation on hepatic health and metabolism remains poorly understood. We sought to investigate this using young female and male APOE3 and APOE4 targeted replacement mice. We also used APOE isogenic induced pluripotent stem cell (iPSC)-derived hepatocyte-like cells (iHLCs) to examine specific effects in a human-relevant cell mod

SUBMITTER: Lysaker CR 

PROVIDER: S-EPMC12262631 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature