Plasma Proteomic Profiling Reveals Distinct Signatures of Chest CT Phenotypes in Sarcoidosis.

ABSTRACT:

Background

Sarcoidosis is a granulomatous disease of unknown cause with a highly variable clinical course. The inability to predict progressive inflammation, fibrosis, or both underscores the limited understanding of the underlying molecular mechanisms.

Objective

We aimed to identify novel protein signatures associated with distinct pulmonary phenotypes of sarcoidosis, including progressive inflammation, progressive fibrosis, and disease resolution.

Methods

We performed the SomaScan 11K Assay to measure more than 10,000 unique human plasma proteins and compared protein expression between chest CT-defined phenotypes using principal component analysis, differential expression, correlation analysis, and gene set enrichment analysis.

Results

We identified distinct

SUBMITTER: Shastry V 

PROVIDER: S-EPMC12262719 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature