Genome-wide association meta-regression identifies stem cell lineage orchestration as a key driver of acne risk.

ABSTRACT: Over 85% of the population experience acne at some point in their lives, with its severity spanning a quantitative spectrum, from mild, transient outbreaks to more persistent, severe forms of the condition. Moderate to severe disease poses a substantial global burden arising from both the physical and psychological impacts of this highly visible condition. The analytical approach taken in this study aimed to address the impact of variation in the dichotomisation of acne case control status, driven by ascertainment and study design, on effect size estimates across independent genetic association studies of acne. Through a fixed intercept meta-regression framework, we combined evidence genome-wide for association with acne across studies in which case-control status had been ascertained in d

SUBMITTER: Maxwell J 

PROVIDER: S-EPMC12262744 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature