A Novel <i>Plasmodium falciparum Kelch13</i> A675T Mutation and High Levels of Chloroquine and Sulfadoxine-Pyrimethamine Resistance in Burundi.

ABSTRACT: Antimalarial resistance, including failure of artemisinin combination therapy, is increasing in Africa. Molecular surveillance of markers of drug resistance is essential to monitoring drug resistance. Plasmodium falciparum isolates from Cibitoke Province, Burundi were sequenced for ten markers of resistance (including potential background markers conferring kelch-13mediated artemisinin partial resistance) by Illumina or Nanopore sequencing. Plasmepsin-2 and mdr1 copy number variations were typed by digital PCR. Among 157 isolates, no validated pfkelch13 mutations linked to artemisinin partial resistance (ART-R) were detected. However, a novel pfkelch13 mutation, A675T, was identified. A mutation in the same position (A675V) had been found and valid

SUBMITTER: Kayode T 

PROVIDER: S-EPMC12262749 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature