Mapping T cell infiltration patterns in glioma tumor tissue.

ABSTRACT:

Background

The glioma immune repertoire has emerged as a vital point of interest, particularly in the context of immunotherapeutics development and as a key player for prognostic and diagnostic biomarker identification.

Methods

Tumor tissue was collected from glioma patients and targeted immune repertoire sequencing of tumor infiltrating lymphocytes (TIL) from each of the four collected glioma tumor subtypes was performed. Gliomas were stratified based on WHO21 classification to map the TCR landscape of astrocytomas (grade II/III, grade IV), glioblastomas, and oligodendrogliomas.

Results

Following stratification of TCR repertoires and complete clonotype, V-J cassette, and CDR3 analysis, we identified cohort-specific levels of diversity, clonotype sharing, and conserva

SUBMITTER: Hsia T 

PROVIDER: S-EPMC12262756 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature