Artemisinin resistant <i>kelch13</i> R622I and RDT negativity approaching predominance in northern Ethiopia and emerging C580Y of African origin threaten falciparum malaria control.

ABSTRACT: The rise of antimalarial drug-resistant Plasmodium falciparum poses a major threat to malaria treatment, control, and elimination efforts. Mutations in the kelch13 (k13) gene confer artemisinin partial resistance (ART-R), compromising the efficacy of combination therapies. In the Horn of Africa, the validated mutation k13 R622I has rapidly emerged in parallel with other mutations elsewhere in Eastern Africa. To monitor and inform control efforts, we conducted in-depth sampling where R622I was first detected, using molecular inversion probe (MIP) targeted sequencing of key resistance mutations and informative SNPs across the genome. Samples were collected for a year within two districts, Gondar Zuria and Tach Armachiho, representing different ecological zones in

SUBMITTER: Zeleke AJ 

PROVIDER: S-EPMC12262759 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature