Electrical Stimulation for the Induction of Seizures is Safe, Well-tolerated and High-Yield in Children with Drug-Resistant Epilepsy.

ABSTRACT:

Introduction

One third of children with epilepsy develop drug-resistant epilepsy (DRE). Epilepsy surgery is the treatment for DRE, and selecting the surgical target typically requires recording spontaneous seizures during intracranial monitoring with stereoelectroencephalography (sEEG). In adults, induced seizures have been shown to help define surgical targets and are associated with superior surgical outcomes. No published studies focus on the safety, tolerability, and yield of electrical stimulation for the induction of seizures (ESIS) in children.

Methods

Stimulation at 1 Hz and 50 Hz was performed prospectively and comprehensively (all gray matter channels) during sEEG in children and young adults with DRE. Induced seizures were categorized into four groups: electroclin

SUBMITTER: Tarcha L 

PROVIDER: S-EPMC12262793 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature