A genome-wide association study of hidradenitis suppurativa from the VA's Million Veteran Program.

ABSTRACT:

Background

Data from family and twin studies as well as prior genome-wide association meta-analyses suggest that hidradenitis suppurativa (HS) has a hereditary component.

Objective

Identify genetic variants associated with HS.

Methods

A case-control genome-wide association study (GWAS) was performed on participants with a diagnosis of HS defined as at least one instance of ICD9 705.83 or ICD10 L73.2 from participants in the VA's Million Veteran Program.

Results

4,959 participants with HS were identified among 597,819 MVP participants. The multi-population GWAS identified two significant loci associated with HS, including a novel HS-related variant on chromosome 6 near HLA-DRB1 (lead variant rs679242), and confirmed a previously identified locus on chromo

SUBMITTER: Wendland Z 

PROVIDER: S-EPMC12262797 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature