NF1-specific growth charts for head circumference over the first three years of life.

ABSTRACT:

Background and objectives

Macrocephaly is among the most common findings in neurofibromatosis type 1 (NF1) and may be associated with other clinical manifestations of the genetic syndrome. NF1-specific growth charts that account for expected macrocephaly may increase sensitivity to detect atypical growth. We aimed to produce NF1-specific growth charts of head circumference for the age range of 0 to 3 years and to assess their potential clinical impact.

Methods

Using electronic health records from the Children's Hospital of Philadelphia, we collected head circumference measurements from children with NF1 and a community control cohort seen at scheduled well-child visits. We compared head circumference normed using Center for Disease Control (CDC) growth charts between these g

SUBMITTER: Mandal AS 

PROVIDER: S-EPMC12262801 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature