Cortical dissociation of spatial reference frames during place navigation.

ABSTRACT: Animals rely on both sensory perception and memory when navigating relative to learned allocentric locations. Incoming sensory stimuli, which arrive from an egocentric perspective, must be integrated into an allocentric reference frame to allow neural computations that direct an animal toward a learned goal. This egocentric-allocentric spatial transformation has been proposed to involve projections from the rodent postrhinal cortex (POR), which receives strong visual input, to the medial entorhinal cortex (MEC), which contains allocentric spatial cell types such as grid and border cells. A major step toward understanding this transformation is to identify how POR and MEC spatial representations differ during place navigation, which is currently unknown. To answer this question, we recorded

SUBMITTER: LaChance PA 

PROVIDER: S-EPMC12262825 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature