Linking genetic and phenotypic bedaquiline resistance in Mycobacterium tuberculosis strains from Georgia.

ABSTRACT:

Introduction

Resistance to bedaquiline - a novel, promising medication against tuberculosis (TB), is already emerging, and uncertainties regarding the role of the different resistance-conferring mutations complicate the development of molecular diagnostic tools for detecting resistance. Mutations in the three genes atpE, pepQ, and Rv0678 have been associated with increased minimum inhibitory concentrations (MICs) to bedaquiline in Mycobacterium tuberculosis (Mtb). Here, we studied the effect of known and novel mutations in these genes on the phenotypic susceptibility to bedaquiline in Mtb isolates from patients with drug-resistant TB in the country of Georgia.

Methods

We used retrospective Mtb isolates (2011-2019) with whole-genome sequencing data, and prospectively collecte

SUBMITTER: Maghradze N 

PROVIDER: S-EPMC12262877 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature