Cardiac digital twins at scale from MRI: Open tools and representative models from ~ 55000 UK Biobank participants.

ABSTRACT: A cardiac digital twin is a virtual replica of a patient's heart for screening, diagnosis, prognosis, risk assessment, and treatment planning of cardiovascular diseases. This requires an anatomically accurate patient-specific 3D structural representation of the heart, suitable for electro-mechanical simulations or study of disease mechanisms. However, generation of cardiac digital twins at scale is demanding and there are no public repositories of models across demographic groups. We describe an automatic open-source pipeline for creating patient-specific left and right ventricular meshes from cardiovascular magnetic resonance images, its application to a large cohort of [Formula: see text] participants from UK Biobank, and the construction of the most comprehensive cohort of adult heart m

SUBMITTER: Ugurlu D 

PROVIDER: S-EPMC12262899 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature