SLC1A5-dependent glutamine uptake in hepatocytes promotes liver regeneration.

ABSTRACT:

Background

The liver's remarkable regenerative capacity after injury restores essential functions for maintaining homeostasis. Understanding molecular circuits initiating liver regeneration leads to new therapies. Solute carrier family 1, member 5 (SLC1A5) is a key glutamine transporter crucial for hepatocyte proliferation. This study investigates the role of SLC1A5 in hepatocytes during liver regeneration and explores its underlying mechanisms.

Methods

We retrieved a hepatocyte-RNA sequencing dataset from mice post-PHx (GSE181761) and a single-nucleus-RNA sequencing dataset from human livers (GSE223561). THLE-2 human hepatocyte cell line was used to study SLC1A5 function in vitro, while magnetic nanoparticles carrying thyroxine-binding globulin (TBG)-promoter-driven Slc1a5

SUBMITTER: Duan Y 

PROVIDER: S-EPMC12262948 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature