Genome-wide study links cardiometabolic factors to cognition via APOA4-APOA5-ZPR1-BUD13 and other loci in rural Indians.

ABSTRACT:

Introduction

Cardiometabolic risks affect cognition during aging, yet genetic basis for both remain understudied in Indians.

Methods

This study constructs an ancestry-matched Indian haplotype reference panel for genotype imputation of 5111 rural Indians. Single-locus, gene-based, conditional genome-wide association analyses are performed on 20 cognitive and 10 cardiometabolic traits, with subsequent follow-up of identified associations through multimodal functional annotation. Furthermore, causal interrelationships between cardiometabolic and cognitive phenotypes by Mendelian randomization are investigated.

Results

One novel memory-associated and 17 novel cardiometabolic phenotypes-associated (high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein chole

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC12263347 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature