FAT1 mutation-related signature predicts survival risk and tumor immunogenicity in lung adenocarcinoma.

ABSTRACT:

Background

FAT atypical cadherin 1 (FAT1) is a well-known tumor regulator that plays a crucial role in multiple cancer signaling pathways. Its mutations have been linked to tumor progression and immune regulation in various cancers, including lung adenocarcinoma (LUAD). In this study, we aim to identify a FAT1 mutation-related transcriptomic risk signature to assess the survival risks and immune status of LUAD patients.

Methods

A total of 2528 LUAD samples, which included both gene expression profiles and clinicopathologic data, were collected from 12 datasets. Additionally, two datasets treated with immunotherapies were also included to investigate the therapeutic effects.

Results

We constructed a FAT1 mutation molecular signature based on 9 relevant genes. LUAD pati

SUBMITTER: Gao L 

PROVIDER: S-EPMC12263358 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature