Bioinformatics analysis and experimental validation of ferroptosis genes in heart failure and atrial fibrillation.

ABSTRACT:

Background and objectives

Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular diseases associated with significant morbidity and mortality in patients with both conditions. The objective of this research is to enhance our understanding of the shared pathogenesis underlying the two diseases and to identify novel therapeutic targets.

Materials and methods

Differentially expressed genes (DEGs) in heart failure and atrial fibrillation were obtained through the analysis and comparison of transcriptional expression profiles from the Gene Expression Omnibus (GEO) datasets. By integrating these datasets with the known ferroptosis-related genes (FRGs) from GeneCards and PubMed, we identified ferroptosis-related differentially expressed genes (FRDEGs). Functional

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12263363 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature