The Variant rs7665090 Is Associated With Interferon-Beta Response in Multiple Sclerosis Patients.

ABSTRACT:

Background

GG homozygosity for the risk gene variant rs7665090 has been reported to enhance nuclear factor kappa B (NFκB) activity in T cells from multiple sclerosis (MS) patients. Here, we investigated the association between this polymorphism and the response to different disease-modifying therapies in MS.

Methods

The rs7665090 polymorphism was genotyped in 558 MS patients treated with injectable therapies [IFNβ (n = 213) and glatiramer acetate (n = 55)], oral therapies [dimethylfumarate (n = 97), teriflunomide (n = 41), and fingolimod (n = 37)], and natalizumab (n = 115). Treatment response was assessed after 1 year for injectable therapies using the Rio Score, which considers relapses, EDSS progression, and radiological activity on MRI. For oral therapies and natalizumab

SUBMITTER: Vilaseca A 

PROVIDER: S-EPMC12263501 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature