Mendelian randomization analysis of gut microbiota-immune cell interactions in malignant neoplasm of nasopharynx.

ABSTRACT: Observational studies have suggested associations among the gut microbiome, immune cells, and the risk of malignant neoplasms of nasopharynx. However, the causality of these relationships remains unclear. Thus, we conducted multiple Mendelian Randomization analyses to estimate the causal association of gut microbiota with the risk of malignant neoplasms of nasopharynx and to evaluate the mediating effect of immune cells on this causal pathway. Genetic variants extracted from genome-wide association studies of human gut microbiota compositions (n = 211), immune cell traits (n = 731) and malignant neoplasms of nasopharynx served as instrumental variables for calculating causal associations and mediating effects. Four gut microbiota compositions and eight immune cell traits exhibited detrimen

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12263519 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature