Comprehensive analysis of exosome-related gene signature in multiple myeloma prognosis and immune microenvironment evaluation.

ABSTRACT: Multiple myeloma (MM) is a genetically complicated plasma cell malignancy characterized by malignant plasma cell proliferation and monoclonal immunoglobulin synthesis. As a disease that remains incurable, enhancing prognostic accuracy is of paramount importance. Tumor-derived exosomes (TDEs) play key roles in modulating the tumor microenvironment, angiogenesis and immune system. Exosomes are involved in multiple processes contributing to cancer progression, including in MM. However, the connection between myeloma and exosome-related genes (ERGs) has not been explored. Therefore, we aim to establish a more accurate model to evaluate the prognosis of MM patients based on the exosome-related genes. This study established an ERG-based prognostic model for MM and investigated its association wi

SUBMITTER: Zheng D 

PROVIDER: S-EPMC12263527 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature