Depletion of UBAP2L suppresses colorectal cancer cell proliferation and radiotherapy resistance by regulating GPX4.

ABSTRACT:

Background

The aim of this study is to investigate the potential role of UBAP2L in the proliferation and radiotherapy resistance of colorectal (CRC) cells.

Methods

Clinical and pathological data were collected from 257 patients with stage I-III primary CRC who underwent surgical treatment at the Affiliated Hospital of Qingdao University (Qingdao, China) and Shandong Electric Power Central Hospital (Shandong China) from 2015 to 2019. Additionally, tumor biopsy specimens were collected from 30 patients with locally advanced rectal cancer. The expression of UBAP2L in CRC tissues was tested using immunochemistry. The association of UBAP2L expression with clinicopathological data and outcomes of patients with CRC was determined. Overexpression and knockdown cells were constructed

SUBMITTER: Li Y 

PROVIDER: S-EPMC12263742 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature