Longitudinal evaluation of serum neurofilament light levels in normal healthy volunteers: defining a threshold of concern.

ABSTRACT: Neurofilament light (NfL) is a neuron-specific protein integral to neuronal cytoskeletons. Upon damage to the central or peripheral nervous system (NS), NfL is released into cerebrospinal fluid and blood. Elevated serum or plasma NfL levels have been reported in a variety of diseases and NS injury states. However, although intraindividual longitudinal NfL changes may be more meaningful than NfL measurements at a single timepoint, data on the longitudinal variation of NfL in normal healthy volunteers (NHV) are scarce. We investigated normal variation in NHV serum NfL and estimate an upper limit of normal (ULN) of NfL variation in longitudinal samples. An initial cross-sectional screening in sera from 270 NHV using a 4-plex assay detected NfL in 99.6% and glial fibrillary acidic protein (GFA

SUBMITTER: Lanz TA 

PROVIDER: S-EPMC12263756 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature