Advanced therapeutic strategy for managing surgical site infections with natural nanoemulsion-antimicrobial combination.

ABSTRACT:

Introduction

Surgical site infections (SSIs) are a significant cause of morbidity and mortality, often complicated by multidrug-resistant (MDR) pathogens and biofilm formation. This study evaluates the potential of a natural nanoemulsion containing chitosan, lavender, and curcumin, in combination with antimicrobial drugs, for treating SSIs.

Methods

A comprehensive approach combining phenotypic and genotypic analyses, along with in vitro and in vivo studies, was used to assess the efficacy and safety of the combination therapy.

Results

The most common SSI pathogens identified were Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, with 50% exhibiting MDR, biofilm format

SUBMITTER: Alshehri F 

PROVIDER: S-EPMC12263955 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature