TNFAIP2 deficiency drives formation of an immunosuppressive tumor microenvironment and confers resistance to anti-PD-1 therapy in skin cutaneous melanoma.

ABSTRACT: TNFα-induced protein 2 (TNFAIP2) reportedly plays a significant role in the initiation and progression of malignancy. However, its function in skin cutaneous melanoma (SKCM) is largely unknown and urgently needs to be explored. Analysis of a publicly available database revealed that TNFAIP2 was significantly downregulated in SKCM tissues vs. normal controls (P < 0.001) and that its expression was a significant indicator for SKCM diagnosis (AUC = 0.742). Patients with low TNFAIP2 expression tended to have tumors in advanced clinical stages with a poor prognosis (P < 0.01), which was validated in our cohort. Subsequent enrichment analysis revealed that genes differentially expressed between SKCM tissues with high and low TNFAIP2 expression were highly enriched in with multiple tumor immune s

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12264008 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature