Hepcidin, incident heart failure, and cardiac dysfunction in older adults: the ARIC study.

ABSTRACT:

Aims

Hepcidin regulates plasma and tissue iron levels. We studied the association of hepcidin levels with the risk of incident heart failure (HF) and cardiac dysfunction in older adults.

Methods and results

We included adults from the ongoing, longitudinal Atherosclerosis Risk in Communities (ARIC) study, who were free from prevalent anaemia and HF at Visit 5 (2011-13) and had available hepcidin and covariate data. Associations of plasma hepcidin levels with overall adjudicated incident HF, HF with reduced ejection fraction (HFrEF), and HF with preserved ejection fraction (HFpEF) were assessed using multivariable Cox proportional hazards regression models. Cross-sectional associations of hepcidin with echocardiographic measures of cardiac structure and function were estimate

SUBMITTER: Aboelsaad IAF 

PROVIDER: S-EPMC12264026 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature