Doxorubicin treatment has a biphasic effect over time on dopamine release and impulsive behavior in Wistar rats.

ABSTRACT: Doxorubicin (Dox) is a chemotherapy agent commonly used to treat multiple types of cancers and is associated with cognitive impairment. The goal of this work was to determine the effect of Dox treatment on dopamine release and uptake and behavior in rats. Rats received one dose per week of Dox (2.5 mg/kg, I.V.) and were sacrificed after two or four weeks. Dopamine release and uptake was measured in brain slices with fast-scan cyclic voltammetry (FSCV). A set of rats that received treatment also underwent behavioral testing with the 5-choice serial reaction timed task (5CSRTT) to measure degree of impulsiveness and attention throughout the course of treatment. Dopamine release and uptake increased substantially after treatment with Dox for two weeks compared to controls. After four weeks of

SUBMITTER: Garcia KJ 

PROVIDER: S-EPMC12264033 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature