SERPINB6 Promotes Epithelial-Mesenchymal Transition via PI3K/AKT/mTOR Signalling Pathway in Glioma.

ABSTRACT: Glioma is the most common and highly invasive type of brain cancer in the central nervous system, characterised by a low survival rate and poor prognosis. The role of SERPINB6 has been proven crucial in programmed necrosis and cancer progression. However, its role in glioma has not yet been clearly defined. This study utilised bioinformatics methods and in vitro and in vivo experiments to assess the expression, function and potential mechanisms of SERPINB6 in the development of glioma. Our study found that SERPINB6 plays a carcinogenic role in glioma, and its expression level is significantly negatively correlated with patient prognosis. The study also found that inhibiting SERPINB6 expression can hinder the epithelial-mesenchymal transition (EMT) of glioma cells. Conversely, overexpressio

SUBMITTER: Wang D 

PROVIDER: S-EPMC12264082 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature