Regional cerebellar atrophy related to disability and cognitive progression in multiple sclerosis.

ABSTRACT:

Objective

The implications of cerebellar pathology on clinical disease progression in multiple sclerosis (MS) remain unclear. This study investigated regional cerebellar atrophy related to physical disability and cognitive impairment progression.

Methods

We included 331 MS patients and 95 controls (Amsterdam MS Cohort, 229 patients and 58 controls re-evaluated after 5 years). Assessments included baseline MRI, and disability and cognition at baseline and follow up. Cerebellar (sub)cortex was parcellated, volumetric data were determined and related to baseline disability and cognition. Longitudinal progression was explored only for regions with significant baseline correlations.

Results

At baseline, patients had mild disability (median EDSS 3.0) and 46% showing mild-to

SUBMITTER: Strik M 

PROVIDER: S-EPMC12264214 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature