Elevated SGO2 expression in lung adenocarcinoma promotes migration and invasion via MAD2 and correlates with poor prognosis.

ABSTRACT: Lung adenocarcinoma is a globally prevalent malignant tumor with a high death rate, notorious for its invasive and metastatic capabilities. SGO2 is a key protein in the cell division process, influencing the development of various malignant tumors. However, research on the biological functions of SGO2 in Lung adenocarcinoma remains limited. By utilizing the Cancer Genome Atlas (TCGA) database, we performed an analysis of SGO2 expression levels in a cohort comprising 206 Lung adenocarcinoma patients in comparison to 200 non-neoplastic control specimens. Subsequently, we validated our findings through immunohistochemical staining in a subset of 21 Lung adenocarcinoma cases from Nanjing Second Hospital. Furthermore, the functional role of SGO2 in the H1299 cell line was assessed through a ser

SUBMITTER: Sun M 

PROVIDER: S-EPMC12264263 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature