Importance of Preserved Ratio Impaired Spirometry as a Risk Factor for Development of COPD, Also in Those Who Do Not Smoke.

ABSTRACT:

Background

COPD is largely underdiagnosed. Active identification of cases is crucial to establish preventive measures before manifestation of clinical disease. The significance of different spirometric patterns preceding COPD, especially preserved ratio impaired spirometry (PRISm), has been highlighted but remains unclear.

Research question

Which clinical characteristics, smoking habits, and spirometric patterns, with primary focus on PRISm findings, precede the development of airway obstruction (AO)?

Study design and methods

The OLIN COPD Study was established from 2002 through 2004. After re-examination of population-based cohorts, individuals with AO (n = 993; FEV₁ to VC ratio < 0.70) were identified together with control participants without AO (n = 993

SUBMITTER: Backman H 

PROVIDER: S-EPMC12264347 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature