Performance change while learning novel cognitive tasks as a potential identifier of preclinical Alzheimer's disease.

ABSTRACT:

Background

In healthy older adults (OA), the effects of amyloid-β (Aβ) deposition on cognitive functions involved in learning are unclear.

Objective

This study aimed to determine how age, practice, and neuropsychological test performance are associated with performance change during the learning of three cognitive tasks, and if Aβ deposition impacts performance change in OA.

Methods

Fifty-five OA and 28 young adults completed neuropsychological tests, and Aβ deposition was assessed in OA. Participants learned three cognitive tasks: stop-go normal task (SGNT), stop-go reverse task (SGRT), and n-back task (NBT). Performance change was analyzed as change in accuracy and reaction time from the first to second and the first to third practice trials using linear mixe

SUBMITTER: Hetrick LM 

PROVIDER: S-EPMC12264413 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature