Detectable Hepatitis B Virus (HBV) PreS Deletion Mutants at Baseline Predicted Delayed Immune Reconstitution and Increased Inflammation in People With Human Immunodeficiency Virus and HBV Coinfection Undergoing Long-term Antiretroviral Therapy.

ABSTRACT: Human immunodeficiency virus (HIV) and hepatitis B virus (HBV) coinfection is common due to similar routes of transmission. Even though antiretroviral therapy (ART) regimens containing tenofovir suppressed HIV and HBV effectively, slower CD4⁺ T-cell recovery was still reported in people with HIV/HBV coinfection. Here, a large and longitudinal treated HIV/AIDS cohort including HBV-coinfected individuals was enrolled, and people with HIV/HBV coinfection were categorized into groups with or without deletion mutants based on the PreS sequence of HBV in plasma at treatment baseline. Subsequent to >4 years of ART, longitudinal CD4⁺ T-cell counts and CD4/CD8 ratios were consistently lower and inflammatory cytokines such as IL-10, IL-18, IP-10, MCP-1, and IFN-γ were significa

SUBMITTER: Lan X 

PROVIDER: S-EPMC12264427 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature