Decreased Antimicrobial Resistance Gene Richness Following Fecal Microbiota, Live-jslm (REBYOTA®) Administration: Post Hoc Analysis of PUNCH CD3.

ABSTRACT:

Background

The human gastrointestinal microbiome helps maintain vital functions related to overall health, including resistance to pathogen colonization. Disruption of the microbiome, leading to loss of colonization resistance, can be caused by multiple factors, including antimicrobial use. The loss of colonization resistance may lead to establishment or proliferation of opportunistic bacteria that carry genes associated with antimicrobial resistance, potentially increasing the risk of infection by such antimicrobial-resistant bacteria. A potential approach to mitigating this risk involves restoration of healthier microbiota and pathogen colonization resistance.

Methods

A metagenomic sequencing method was used to conduct a post hoc analysis of antibiotic resistance gene rich

SUBMITTER: Adamowicz E 

PROVIDER: S-EPMC12264430 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature