[¹⁸F]SynVest-1 PET imaging in people with Parkinson's disease.

ABSTRACT: The [¹⁸F]SynVest-1 radiotracer targets the synaptic vesicle glycoprotein 2A (SV2A) and is a proxy of presynaptic density. Parkinson's disease is associated with synaptic dysfunction. Here we investigated synaptic density via the [¹⁸F]SynVest-1 radiotracer in people with PD compared with healthy controls, with reference to how it compares to the previous SV2A radiotracer, [11C]UCB-J. Ten Parkinson's patients and 12 healthy subjects underwent a [¹⁸F]SynVest-1 PET scan. We compared non-displaceable binding potential via voxel-wise and volume of interest analysis to investigate group differences. Volume-of-interest-analyses reported lower non-displaceable binding potential in key a priori regions associated with Parkinson's disease, namely the substantia nigra

SUBMITTER: Martin SL 

PROVIDER: S-EPMC12264488 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature