Motor network organization in healthy development and chronic tic disorders.

ABSTRACT: Tic disorders (TD) are childhood-onset neurodevelopmental disorders characterized by sudden, repetitive motor and vocal tics, often with partial or complete remission by the time young adulthood is reached. We here investigated motor control and compensatory neural processes in drug-naïve children and adolescents with chronic Motor Tic Disorder or Tourette Syndrome (TD) by examining motor network activity and connectivity compared to healthy controls. Using a reaction time (RT) task under varying cueing conditions, combined with functional magnetic resonance imaging (fMRI) and dynamic causal modelling (DCM), we explored how TD-related motor networks adapt to support volitional movement control. Participants with TD demonstrated enhanced task accuracy across internally and externally cued c

SUBMITTER: Heinen TV 

PROVIDER: S-EPMC12264489 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature