Serum 25-Hydroxyvitamin D and Intact Parathyroid Hormone as Functional Biomarkers of Bone Mass in Early Childhood.

ABSTRACT:

Background

The 25-hydroxyvitamin D (25(OH)D) concentration at which parathyroid hormone (PTH) concentration plateaus has been considered to benchmark vitamin D deficiency. However, in young children, there is limited evidence for a suppression point in the 25(OH)D-PTH relationship or its relevance to bone mass accrual.

Objectives

To determine whether the threshold of 25(OH)D at PTH suppression in young children is corroborated by associations of 25(OH)D (or PTH) with bone mineral content (BMC) and areal bone mineral density (aBMD).

Methods

In a cross-sectional secondary analysis of data from the BONe and mUScle health in Kids (BONUSKids) study of 4-y-old children in Bangladesh, serum 25(OH)D and intact PTH (iPTH) were analyzed by liquid chromatography-tandem mass spec

SUBMITTER: O'Callaghan KM 

PROVIDER: S-EPMC12264547 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature