Application of preclinical absorption, distribution, metabolism, elimination in vitro techniques for the characterization and compound library optimization of novel antibiotic gallium salophen.

ABSTRACT: Multidrug-resistant pathogens are an emerging threat to public health. Metal-based drugs have shown antimicrobial properties. As a result, metallotherapeutics have an untapped potential to combat antibiotic-resistant infections. Characterization of additional physiochemical attributes is needed to progress metallodrugs in the clinical pipeline. In order to fully characterize a modest library of compounds based on novel therapeutic gallium salophen (GaSal), target binding affinity (dissociation constant, K_d), lipophilicity (octanol-water partition coefficient, logP), protein binding (fraction of protein bound compound, K_b), Caco-2 permeability, microsomal stability, and blood/plasma partitioning (blood-plasma partition coefficient, K_RBC/PL) experi

SUBMITTER: Krug SA 

PROVIDER: S-EPMC12264554 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature