The Interplay of Dietary Choline and Methyl Donors in Modulating Maternal Inflammation: Insights from Project Viva.

ABSTRACT:

Background

Inflammation during pregnancy is an important contributor to maternal and offspring morbidity and mortality. Evidence from both nonpregnant human and animal studies suggests that dietary choline can attenuate inflammation, but this has not yet been explored in human pregnancy.

Objectives

This study explored the cross-sectional associations between maternal mid-pregnancy dietary choline intake and inflammation biomarkers, specifically IL-6, tumor necrosis factor- α (TNF-α), and C-reactive protein (CRP), while also examining the modifying effects of other methyl donor nutrients.

Methods

We analyzed data from 640 pregnant women enrolled in Project Viva, a longitudinal cohort study in Eastern Massachusetts. We assessed mid-pregnancy maternal dietary intake via

SUBMITTER: Larson EA 

PROVIDER: S-EPMC12264560 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature