Diagnostic yield in families to sudden cardiac death victims: a 10-year follow-up study.

ABSTRACT:

Aims

Up to 70% of sudden cardiac death (SCD) cases in younger individuals are potentially caused by an inherited heart disease. However, long-term diagnostic yield and risk of cardiac events in SCD relatives remain unclear. This study aimed to determine the 10-year diagnostic yield of inherited heart diseases and frequency of cardiac events in SCD relatives.

Methods and results

This retrospective study included SCD probands and their relatives referred to the Unit for Inherited Heart Diseases at Rigshospitalet, Denmark, from 2005 to 2018. Relatives underwent guideline-recommended screening and follow-up. Diagnoses and cardiac events, such as new-onset reduced left ventricular ejection fraction ≤45%, sustained ventricular tachycardia, appropriate implantable cardioverter-defi

SUBMITTER: Gronholdt CL 

PROVIDER: S-EPMC12264593 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature