Difference of Resting State Functional Connectivity between Depressive Patients with and without Clinically Significant Insomnia.

ABSTRACT:

Objective

Insomnia is a common symptom of major depressive disorder (MDD). However, the neural distinctions between MDD with and without insomnia remain unclear. This study investigated resting state functional connectivity (RSFC), specifically seeding the habenula and septal nuclei, to identify neurobiological abnormalities associated with insomnia in MDD.

Methods

Thirty-six patients with MDD and clinically significant insomnia (MDD_w/INS), 21 patients without insomnia (MDD_wo/INS), and 38 healthy controls underwent 3T resting-state fMRI. Seed-to-voxel RSFC analyses were conducted using the habenula and septal nuclei as seeds. Between-group comparisons and correlation analyses were adjusted for age, sex, years of education, and Hamilton Depression Rating Scale 17 items (HDR

SUBMITTER: Jung JY 

PROVIDER: S-EPMC12264675 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature